解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::This study investigated the effects of progesterone (P4) on the production and survival of neurons in the hippocampal dentate gyrus of adult male mice. The administration of P4 (4 mg/kg) for 3 consecutive days beginning on the 0-2nd day after the first BrdU-injection (BrdU-D(0-2)) produced an approximately twofold inc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20642
更新日期:2010-03-01 00:00:00
abstract::The mechanism supporting the role of the hippocampal formation in novelty detection remains controversial. A comparator function has been variously ascribed to CA1 or subiculum, whereas the theta rhythm has been suggested to separate neural firing into encoding and retrieval phases. We investigated theta phase of firi...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20671
更新日期:2010-02-01 00:00:00
abstract::Dual-process theories of episodic memory state that retrieval is contingent on two independent processes: familiarity (providing a sense of oldness) and recollection (recovering events and their context). A variety of studies have reported distinct neural signatures for familiarity and recollection, supporting dual-pr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20606
更新日期:2010-02-01 00:00:00
abstract::Previous investigation of CA1-evoked subicular responses has used either single low-frequency pulses (LF), paired-pulses (PP), or high-frequency bursts. Here we test for the first time how subiculum responds to naturalistic stimulation trains (NSTs). We recorded CA1-evoked field potentials from dorsal rat subiculum in...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20629
更新日期:2010-02-01 00:00:00
abstract::Trans-synaptic cell-adhesion molecules have been implicated in regulating CNS synaptogenesis. Among these, the Neuroligin (NL) family (NLs 1-4) of postsynaptic adhesion proteins has been shown to promote the development and specification of excitatory versus inhibitory synapses. NLs form a heterophilic complex with th...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20630
更新日期:2010-02-01 00:00:00
abstract::Hippocampal neurogenesis declines substantially in chronic temporal lobe epilepsy (TLE). However, it is unclear whether this decline is linked to altered production of new cells and/or diminished survival and neuronal fate-choice decision of newly born cells. We quantified different components of hippocampal neurogene...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20594
更新日期:2010-01-01 00:00:00
abstract::Despite evidence that the extracellular matrix glycoprotein tenascin-C (TNC) is implicated in brain development and plasticity, its roles in the intact adult brain are unknown. Here we report that spontaneous local field potential (LFP) activity in freely moving adult TNC-deficient mice is abnormal. The power of corti...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20585
更新日期:2009-12-01 00:00:00
abstract::The modulatory actions of GABA(A) receptor subunits are crucial for morphological and transcriptional neuronal activities. In this study, growth of hamster hippocampal neurons on biohybrid membrane substrates allowed us to show for the first time that the two major GABA(A) alpha receptor subunits (alpha(2,5)) are capa...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20584
更新日期:2009-11-01 00:00:00
abstract::Social isolation negatively affects the behavior and health of laboratory rats. Recently, it has been found that social isolation retards exercise-induced neurogenesis in the hippocampal dentate gyrus (DG) of male rats (Stranahan et al. (2006) Nat Neurosci 9:526-533). Since male and female rats react differently to ho...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20563
更新日期:2009-10-01 00:00:00
abstract::The past decade has witnessed burgeoning evidence that antidepressant medications and physical exercise increase the expression of hippocampal brain-derived neurotrophic factor (BDNF). This phenomenon has gained widespread appeal, because BDNF is one of the first macromolecules observed to play a central role not only...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20579
更新日期:2009-10-01 00:00:00
abstract::Short periods of forced exercise have been reported to selectively induce enhancements in hippocampal-dependent cognitive function, possibly via brain-derived neurotrophic factor (BDNF)-mediated mechanisms. In this study, we report that 1 week of treadmill running significantly enhanced both object displacement (spati...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20631
更新日期:2009-10-01 00:00:00
abstract::It has been well-established that cell proliferation and neurogenesis in the adult mouse dentate gyrus (DG) can be regulated by voluntary exercise. Recent evidence has suggested that the effects of voluntary exercise can in turn be influenced by environmental factors that regulate the amount of stress an animal is exp...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20514
更新日期:2009-10-01 00:00:00
abstract::Galantamine, a novel Alzheimer's drug, is known to inhibit acetylcholinesterase activity and potentiate nicotinic acetylcholine receptor (nAChR) in the brain. We previously reported that galantamine potentiates the NMDA-induced currents in primary cultured rat cortical neurons. We now studied the effects of galantamin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20572
更新日期:2009-09-01 00:00:00
abstract::The functional organization of the perforant path input to the dentate gyrus of the exposed hippocampus was studied in adult rabbits anesthetized with urethane and chloralose. Electrical stimulation of perforant path fibers caused excitation of granule cells along narrow, nearly transverse strips (lamellae) of tissue....
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20538
更新日期:2009-07-01 00:00:00
abstract::In this article, we present a framework to perform statistical shape analysis for segmented hippocampi, including an efficient permutation test for detecting subtle class differences, and a regularized discriminative direction method for visualizing the shape discrepancy. Fisher permutation and bootstrap tests are pre...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20639
更新日期:2009-06-01 00:00:00
abstract::Temporal difference learning (TD) is a popular algorithm in machine learning. Two learning signals that are derived from this algorithm, the predictive value and the prediction error, have been shown to explain changes in neural activity and behavior during learning across species. Here, the predictive value signal is...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20535
更新日期:2009-05-01 00:00:00
abstract::The effects of selective ibotenate lesions of the complete hippocampus (CHip), the hippocampal ventral pole (VP), or the medial prefrontal cortex (mPFC) in male rats were assessed on several measures related to energy regulation (i.e., body weight gain, food intake, body adiposity, metabolic activity, general behavior...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20499
更新日期:2009-03-01 00:00:00
abstract::An extensive cortical network consisting of structures in the medial temporal lobe (hippocampus and parahippocampal cortex), lateral parietal cortex, retrosplenial cortex, and medial prefrontal cortex has recently attracted attention in cognitive neuroscience research, linking the network to both episodic memory and s...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20490
更新日期:2009-02-01 00:00:00
abstract::Pituitary adenylate cyclase-activating polypeptide (PACAP), a neurotrophic and neuromodulatory peptide, was recently shown to enhance NMDA receptor-mediated currents in the hippocampus (Macdonald, et al. 2005. J Neurosci 25:11374-11384). To check if PACAP might also modulate AMPA receptor function, we tested its effec...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20488
更新日期:2009-01-01 00:00:00
abstract::Rats use time-of-day cues to modulate learned taste aversion memories. If adult rats are accustomed to drinking saline in the evening and they receive a lithium chloride injection after drinking saline in the morning, they form a stronger aversion to saline than rats that were conditioned after drinking saline at the ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20481
更新日期:2009-01-01 00:00:00
abstract::Our previous study showed that kainate (KA) receptor subunit GluR6 played an important role in ischemia-induced MLK3 and JNK activation and neuronal degeneration through the GluR6-PSD95-MLK3 signaling module. However, whether the KA receptors subunit GluR6 is involved in the activation of p38 MAP kinase during the tra...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20479
更新日期:2009-01-01 00:00:00
abstract::We aimed at identifying the cerebral structures whose synaptic function subserves the recollection of lifetime's episodic autobiographical memory (AM) via autonoetic consciousness. Twelve healthy middle-aged subjects (mean age: 59 years +/- 2.5) underwent a specially designed cognitive test to assess the ability to re...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20406
更新日期:2008-01-01 00:00:00
abstract::Two patients, with magnetic resonance imaging (MRI)-confirmed relatively selective hippocampal damage, showed distinct patterns of performance on tests of recall, item recognition, and associative recognition. Patient AC showed a mean bilateral volume reduction of the hippocampus of 28%, but displayed no memory defici...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20427
更新日期:2008-01-01 00:00:00
abstract::Granule cells of the mouse fascia dentata are widely used in studies on neuronal development and plasticity. In contrast to the rat, however, high-resolution morphometric data on these cells are scarce. Thus, we have analyzed granule cells in the fascia dentata of the adult Thy1-GFP mouse (C57BL/6 background). In this...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20398
更新日期:2008-01-01 00:00:00
abstract::Paired-pulse depression (PPD), a short-term neural plasticity, was studied in hippocampal CA1 of urethane-anesthetized rats in vivo, using field potential recordings and current source density analysis. PPD was robust when an ipsilateral CA3 (iCA3) conditioning pulse of moderate stimulus intensity was followed 30-200 ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20458
更新日期:2008-01-01 00:00:00
abstract::It has been demonstrated that the dorsal CA1 subregion of the hippocampus mediates temporal processing of information, that dorsal CA3 participates in the spatiotemporal processing of memory, and the dorsal dentate gyrus (DG) mediates spatial pattern separation. A temporal ordering of spatial locations task was develo...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20455
更新日期:2008-01-01 00:00:00
abstract::CA3 lesions impair encoding, whereas CA1 lesions impair retrieval during learning of a Hebb-Williams maze. CA3 efferents in the fimbria were transected, taking care to spare cholinergic and GABAergic afferents. CA1 efferents in the dorsal fornix were similarly transected. Fimbria transections, but not dorsal fornix tr...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20429
更新日期:2008-01-01 00:00:00
abstract::Although a large body of evidence indicates that sleep plays an important role in learning and memory processes, the actual existence of a sleep-dependent spatial memory consolidation has been not firmly established. Here, by using a computerized 3D virtual navigation tool, we were able to show that topographical orie...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20444
更新日期:2008-01-01 00:00:00
abstract::The selective lesion of basal forebrain cholinergic neurons (BFCNs) is an unestimable tool to study the implication of these neurons in cognition, an interest widely motivated by their degeneration in Alzheimer's disease. Here we evaluated the histochemical and behavioral effects of a selective lesion of BFCNs in C57B...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20422
更新日期:2008-01-01 00:00:00
abstract::Although the parahippocampal cortex (PHc) is known to be critical for memory formation, little is known about what is encoded by this area. Using multi-voxel pattern analysis of high-resolution functional magnetic resonance imaging (MRI) data, we examined responses to blocks of categorically coherent stimuli and found...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20433
更新日期:2008-01-01 00:00:00
abstract::To clarify the specific contribution of the medial temporal lobe structures in spatial memory, we tested monkeys (Macaca mulatta) with sham operations and with lesions of either the hippocampal formation, areas TH/TF or perirhinal cortex on two versions of the visual-paired comparison task, measuring Spatial Location,...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20369
更新日期:2008-01-01 00:00:00
abstract::The locomotor effects of intra-NAcc injection of dopamine receptor agonists following discrete lesion or inhibition of the DH or the VH have been poorly investigated using only the indirect dopamine receptor agonist amphetamine. In the present study, we investigated how lidocaine in the DH or the VH modulated hyperloc...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20337
更新日期:2007-01-01 00:00:00
abstract::Ontogenesis of GABAergic signaling may play an important role in developmental changes in seizure susceptibility in the high-potassium model of ictogenesis in vitro. The age-dependent effects of [K(+)](o) on the reversal potential of the GABA(A)-mediated responses and membrane potential in hippocampal slices in vitro ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20259
更新日期:2007-01-01 00:00:00
abstract::We have shown previously that chronic nicotine treatment reverses adult-onset hypothyroidism-induced impairment of late-phase long-term potentiation (L-LTP) in area CA1 of the hippocampus. In the present study, basal and stimulated levels of signaling molecules essential for the expression of L-LTP were determined in ...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20306
更新日期:2007-01-01 00:00:00
abstract::A little over 20 years ago, (Teyler and DiScenna,1986; Behav Neurosci 100:147-152) proposed the hippocampal memory index theory. It offered an account of episodic memory based on the intrinsic organization of the hippocampus, its synaptic physiology and its anatomical relationship to other regions of the brain. The es...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20350
更新日期:2007-01-01 00:00:00
abstract::Converging behavioral, electrophysiological, and neurochemical data suggest that lesions to the peripheral vestibular system result in impairment of the hippocampus. Nonetheless, relatively few studies have examined the hippocampus or behavior related to it, over a long period of time following the lesion, to determin...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20266
更新日期:2007-01-01 00:00:00
abstract::Down syndrome (DS), the leading genetic cause of mental retardation, is characterized by reduced number of cortical neurons and brain size. The occurrence of these defects starting from early life stages points at altered developmental neurogenesis as their major determinant. The goal of our study was to obtain compar...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20308
更新日期:2007-01-01 00:00:00
abstract::A couple of papers indicate that patients with depression show a decrease in serum neuropeptide Y (NPY). To study the role of NPY in depression, we examined the effects of infusion of NPY into the hippocampus of learned helplessness (LH) rats (an animal model of depression). Infusion of NPY into the cerebral ventricle...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20264
更新日期:2007-01-01 00:00:00
abstract::It is argued that while the hippocampus is not vital for all classes of configural learning, it is vital for a specific subclass of configural tasks called "structural learning." The defining feature of structural learning is that in addition to binding stimulus elements to make unique arrays (as in all configural lea...
journal_title:Hippocampus
pub_type: 杂志文章,评审
doi:10.1002/hipo.20323
更新日期:2007-01-01 00:00:00
abstract::Intracellular recording and computational modelling suggest that interactions of subthreshold membrane potential oscillation frequency in different dendritic branches of entorhinal cortex stellate cells could underlie the functional coding of continuous dimensions of space and time. Among other things, these interacti...
journal_title:Hippocampus
pub_type: 杂志文章
doi:10.1002/hipo.20374
更新日期:2007-01-01 00:00:00